RIMS2 Antikörper (Center)

Produktnummer ABIN500608

Produktdetails anti-RIMS2 Antikörper

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Bindungsspezifität: Center

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIMS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Rim2. Rim2 is known to exist in multiple isoforms, this antibody should recognize most of them. It is predicted to have no cross-reactivity to other Rim proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: Rim2 antibody was raised against a 17 amino acid peptide near the center of the human Rim2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu RIMS2

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Andere Bezeichnung: RIMS2 (RIMS2 Produkte)

Synonyme: OBOE antikoerper, RAB3IP3 antikoerper, RIM2 antikoerper, 2810036I15Rik antikoerper, AW048769 antikoerper, Rab3ip2 antikoerper, Rim2(+40A) antikoerper, Rim2(+44A) antikoerper, Rim2(+4A) antikoerper, Serg2 antikoerper, Syt3-rs antikoerper, mKIAA0751 antikoerper, Nim2 antikoerper, Rim2 antikoerper, RIMS2 antikoerper, MGC159469 antikoerper, rims2 antikoerper, zgc:73064 antikoerper, drs antikoerper, drsp antikoerper, mema antikoerper, np-a antikoerper, pinin antikoerper, pnn antikoerper, pnn-a antikoerper, pnn-b antikoerper, sdk3 antikoerper, regulating synaptic membrane exocytosis 2 antikoerper, regulating synaptic membrane exocytosis 2a antikoerper, pinin, desmosome associated protein S homeolog antikoerper, RIMS2 antikoerper, Rims2 antikoerper, rims2a antikoerper, pnn.S antikoerper

Hintergrund: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release, synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.Synonyms: KIAA0751, RAB3IP3, RIM 2, RIM2, Rab-3-interacting molecule 2, Rab-3-interacting protein 3, Regulating synaptic membrane exocytosis protein 2

Gen-ID: 9699

NCBI Accession: NP_001093587

UniProt: Q9UQ26

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis