CAB39 Antikörper (AA 201-300) (AbBy Fluor® 750)
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- Target Alle CAB39 Antikörper anzeigen
- CAB39 (Calcium Binding Protein 39 (CAB39))
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Bindungsspezifität
- AA 201-300
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CAB39 Antikörper ist konjugiert mit AbBy Fluor® 750
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human MO25 alpha/CAB39
- Isotyp
- IgG
- Top Product
- Discover our top product CAB39 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- CAB39 (Calcium Binding Protein 39 (CAB39))
- Andere Bezeichnung
- MO25 alpha/CAB39 (CAB39 Produkte)
- Synonyme
- CG4083 antikoerper, Dmel\\CG4083 antikoerper, Dmo25 antikoerper, dMo25 antikoerper, l(3)00274 antikoerper, mo25 antikoerper, fc06a03 antikoerper, zgc:86716 antikoerper, wu:fc06a03 antikoerper, MGC78903 antikoerper, CAB39 antikoerper, MO25 antikoerper, AA408805 antikoerper, AA960512 antikoerper, C78372 antikoerper, MO25alpha antikoerper, CG4083 gene product from transcript CG4083-RA antikoerper, calcium binding protein 39 antikoerper, calcium binding protein 39 L homeolog antikoerper, Cab39 protein antikoerper, Mo25 antikoerper, cab39 antikoerper, cab39.L antikoerper, CAB39 antikoerper, Bm1_33380 antikoerper, Cab39 antikoerper
- Hintergrund
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Synonyms: CAB39, Calcium binding protein 39, CGI 66, CGI66, MO25 alpha, MO25, Mouse protein 25 alpha, Protein Mo25.
Background: Mouse protein 25 alpha (MO25 alpha, CAB39) is a 40- kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle, however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms.
- Gen-ID
- 51719
- Pathways
- AMPK Signaling
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