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SHoc2/Sur8 Antikörper (N-Term)

SHOC2 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500706
  • Target Alle SHoc2/Sur8 (SHOC2) Antikörper anzeigen
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Bindungsspezifität
    • 15
    • 13
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 41
    • 27
    • 20
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 41
    Kaninchen
    Klonalität
    • 41
    Polyklonal
    Konjugat
    • 13
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SHoc2/Sur8 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 19
    • 13
    • 13
    • 5
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects SHOC2.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Andere Bezeichnung
    SHOC2 (SHOC2 Produkte)
    Synonyme
    AU017287 antikoerper, Sur8 antikoerper, mKIAA0862 antikoerper, SIAA0862 antikoerper, SOC2 antikoerper, SUR8 antikoerper, si:ch211-159c12.3 antikoerper, si:ch211-197i12.3 antikoerper, zgc:152956 antikoerper, soc-2 (suppressor of clear) homolog (C. elegans) antikoerper, SHOC2 leucine-rich repeat scaffold protein antikoerper, SHOC2 leucine-rich repeat scaffold protein S homeolog antikoerper, SHOC2, leucine rich repeat scaffold protein antikoerper, Shoc2 antikoerper, shoc2.S antikoerper, SHOC2 antikoerper, shoc2 antikoerper
    Hintergrund
    SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.Synonyms: KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC-2, SOC2, SUR8
    Gen-ID
    8036
    NCBI Accession
    NP_031399
    UniProt
    Q9UQ13
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