SIPA1L3
Reaktivität: Human, Maus, Meerschweinchen
IP
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL
Buffer
PBS containing 0.02 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody (in aliquots) at -20 °C.
Target
SIPA1L3
(Signal-Induced Proliferation-Associated 1 Like 3 (SIPA1L3))
SPAL3 antikoerper, 2610511M17Rik antikoerper, signal induced proliferation associated 1 like 3 antikoerper, signal-induced proliferation-associated 1 like 3 antikoerper, SIPA1L3 antikoerper, sipa1l3 antikoerper, Sipa1l3 antikoerper
Hintergrund
Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice (3) and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.Synonyms: KIAA0545, SPA-1-like protein 3, SPAL3, Signal-induced proliferation-associated 1-like protein 3