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SKI Antikörper (N-Term)

SKI Reaktivität: Human WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500734
  • Target Alle SKI Antikörper anzeigen
    SKI (SKI Proto-Oncogene (SKI))
    Bindungsspezifität
    • 7
    • 3
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 25
    • 20
    • 11
    • 3
    • 3
    Human
    Wirt
    • 22
    • 3
    Kaninchen
    Klonalität
    • 22
    • 3
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser SKI Antikörper ist unkonjugiert
    Applikation
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects Ski. it will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    Ski antibody was raised against a 14 amino acid peptide from near the amino terminus of human Ski.
    Isotyp
    IgG
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    Discover our top product SKI Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SKI (SKI Proto-Oncogene (SKI))
    Andere Bezeichnung
    SKI (SKI Produkte)
    Synonyme
    SGS antikoerper, SKV antikoerper, SKI antikoerper, C-SKI antikoerper, RGD1565591 antikoerper, c-ski antikoerper, 2310012I02Rik antikoerper, 2610001A11Rik antikoerper, AA062172 antikoerper, AA589460 antikoerper, BC004088 antikoerper, ski antikoerper, skv antikoerper, xski antikoerper, id:ibd1250 antikoerper, SKI proto-oncogene antikoerper, ski sarcoma viral oncogene homolog (avian) antikoerper, SKI proto-oncogene L homeolog antikoerper, v-ski avian sarcoma viral oncogene homolog a antikoerper, SKI antikoerper, Ski antikoerper, ski.L antikoerper, skia antikoerper
    Hintergrund
    TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes.Synonyms: Proto-oncogene c-Ski, Ski oncogene, ski oncoprotein, v-ski avian sarcoma viral oncogene homolog
    Gen-ID
    6497
    UniProt
    P12755
    Pathways
    Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development
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