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NOTUM Antikörper (AA 351-450) (AbBy Fluor® 750)

NOTUM Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 750
Produktnummer ABIN5007785
  • Target Alle NOTUM Antikörper anzeigen
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    AA 351-450
    Reaktivität
    • 37
    • 3
    • 2
    Human
    Wirt
    • 37
    Kaninchen
    Klonalität
    • 37
    Polyklonal
    Konjugat
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NOTUM Antikörper ist konjugiert mit AbBy Fluor® 750
    Applikation
    • 33
    • 21
    • 12
    • 12
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NOTUM
    Isotyp
    IgG
    Top Product
    Discover our top product NOTUM Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    Andere Bezeichnung
    NOTUM (NOTUM Produkte)
    Synonyme
    5730593N15Rik antikoerper, RGD1307119 antikoerper, notum, palmitoleoyl-protein carboxylesterase antikoerper, notum pectinacetylesterase homolog (Drosophila) antikoerper, NOTUM, palmitoleoyl-protein carboxylesterase antikoerper, NOTUM antikoerper, Notum antikoerper
    Hintergrund

    Synonyms: NOTUM, notum pectinacetylesterase homolog Drosophila, Notum pectinacetylesterase homolog, NOTUM_HUMAN.

    Background: Notum is a 496 amino acid secreted protein that belongs to the pectinacetylesterase family and may deacetylate GlcNAc residues on cell surface glycans. The gene that encodes Notum consists of approximately 9,334 bases and maps to human chromosome 17q25.3. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5 % of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

    Gen-ID
    147111
    UniProt
    Q6P988
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