SOCS1 Antikörper (N-Term)
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- Target Alle SOCS1 Antikörper anzeigen
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SOCS1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody detects SOCS1 / JAB at N-term.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human
- Aufreinigung
- Peptide affinity chromatography
- Immunogen
- SOCS1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human SOCS1.
- Isotyp
- IgG
- Top Product
- Discover our top product SOCS1 Primärantikörper
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- Applikationshinweise
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS containing 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
- Andere Bezeichnung
- SOCS1 (SOCS1 Produkte)
- Synonyme
- socs1 antikoerper, zgc:91868 antikoerper, jab antikoerper, cis1 antikoerper, ssi1 antikoerper, tip3 antikoerper, cish1 antikoerper, ssi-1 antikoerper, socs-1 antikoerper, SOCS1 antikoerper, LOC100228306 antikoerper, socs1b antikoerper, CIS1 antikoerper, CISH1 antikoerper, JAB antikoerper, SOCS-1 antikoerper, SSI-1 antikoerper, SSI1 antikoerper, TIP3 antikoerper, Cish1 antikoerper, Cish7 antikoerper, Socs-1 antikoerper, suppressor of cytokine signaling 1a antikoerper, suppressor of cytokine signaling 1 antikoerper, suppressor of cytokine signaling 1 L homeolog antikoerper, socs1a antikoerper, socs1 antikoerper, SOCS1 antikoerper, socs1.L antikoerper, Socs1 antikoerper
- Hintergrund
- The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines (1). SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase (2). SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome (3). It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP (4).Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
- Gen-ID
- 8651
- Pathways
- JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus
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