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SPRED1 Antikörper (Center)

SPRED1 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500796
  • Target Alle SPRED1 Antikörper anzeigen
    SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))
    Bindungsspezifität
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 37
    • 7
    Kaninchen
    Klonalität
    • 37
    • 7
    Polyklonal
    Konjugat
    • 20
    • 6
    • 5
    • 5
    • 4
    • 4
    Dieser SPRED1 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 34
    • 20
    • 7
    • 6
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects SPRED1 at center. It is predicted to have no cross-reactivity to Spred2 or Spred3.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    Spred1 antibody was raised against a 20 amino acid peptide near the center of the human Spred1.
    Isotyp
    IgG
    Top Product
    Discover our top product SPRED1 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))
    Andere Bezeichnung
    SPRED1 (SPRED1 Produkte)
    Synonyme
    fb14c08 antikoerper, fj51c03 antikoerper, zgc:85707 antikoerper, wu:fb14c08 antikoerper, wu:fj51c03 antikoerper, Xspred1 antikoerper, Xtspred1 antikoerper, 5730461F13Rik antikoerper, AL024345 antikoerper, AW047647 antikoerper, NFLS antikoerper, hSpred1 antikoerper, spred-1 antikoerper, sprouty-related, EVH1 domain containing 1 antikoerper, sprouty related EVH1 domain containing 1 antikoerper, sprouty related, EVH1 domain containing 1 antikoerper, sprouty related, EVH1 domain containing 1 L homeolog antikoerper, SPRED1 antikoerper, sprouty protein with EVH-1 domain 1, related sequence antikoerper, spred1 antikoerper, SPRED1 antikoerper, spred1.L antikoerper, Bm1_51610 antikoerper, Spred1 antikoerper
    Hintergrund
    The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes, it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).Synonyms: EVH1/Sprouty domain containing protein, NFLS, Spred-1, Suppressor of Ras/MAPK activation
    Gen-ID
    161742
    NCBI Accession
    NP_689807
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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