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TIGAR Antikörper (Center)

TIGAR Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500907
  • Target Alle TIGAR Antikörper anzeigen
    TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
    Bindungsspezifität
    • 15
    • 12
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 37
    • 33
    • 4
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 57
    • 1
    • 1
    Kaninchen
    Klonalität
    • 59
    Polyklonal
    Konjugat
    • 24
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TIGAR Antikörper ist unkonjugiert
    Applikation
    • 40
    • 26
    • 13
    • 13
    • 9
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects TIGAR at center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    TIGAR antibody was raised against a 18 amino acid peptide from near the center of human TIGAR.
    Isotyp
    IgG
    Top Product
    Discover our top product TIGAR Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
    Andere Bezeichnung
    TIGAR (TIGAR Produkte)
    Synonyme
    AA793651 antikoerper, AI595337 antikoerper, C79710 antikoerper, C85509 antikoerper, Tigar antikoerper, Trp53 induced glycolysis repulatory phosphatase antikoerper, Tigar antikoerper
    Hintergrund
    The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.Synonyms: 6-bisphosphatase TIGAR, C12orf5, Probable fructose-2, TP53-induced glycolysis and apoptosis regulator
    Gen-ID
    57103
    NCBI Accession
    NP_065108
    Pathways
    Warburg Effekt
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