FIP200 Antikörper (AA 501-600) (AbBy Fluor® 680)
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- Target Alle FIP200 (RB1CC1) Antikörper anzeigen
- FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))
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Bindungsspezifität
- AA 501-600
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Reaktivität
- Huhn
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FIP200 Antikörper ist konjugiert mit AbBy Fluor® 680
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Huhn
- Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human RB1CC1
- Isotyp
- IgG
- Top Product
- Discover our top product RB1CC1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))
- Andere Bezeichnung
- RB1CC1 (RB1CC1 Produkte)
- Synonyme
- DKFZp459E2330 antikoerper, CC1 antikoerper, FIP200 antikoerper, 2900055E04Rik antikoerper, 5930404L04Rik antikoerper, Cc1 antikoerper, LaXp180 antikoerper, RB1 inducible coiled-coil 1 antikoerper, RB1 inducible coiled-coil 1 L homeolog antikoerper, RB1-inducible coiled-coil 1 antikoerper, RB1CC1 antikoerper, rb1cc1.L antikoerper, rb1cc1 antikoerper, Rb1cc1 antikoerper
- Hintergrund
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Synonyms: CC1, ATG17, FIP200, PPP1R131, RB1-inducible coiled-coil protein 1, FAK family kinase-interacting protein of 200 kDa, RB1CC1, KIAA0203, RBICC
Background: Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.
- Gen-ID
- 9821
- UniProt
- Q8TDY2
- Pathways
- Regulation of Cell Size, Autophagie
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