TMED10 Antikörper (Center)

Produktnummer ABIN500992

Produktdetails anti-TMED10 Antikörper

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMED10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects TMED10 / TMP21 at Center.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: TMP21 antibody was raised against a 18 amino acid peptide from near the center of human TMP21.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu TMED10

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Andere Bezeichnung: TMED10 / TMP21 (TMED10 Produkte)

Synonyme: tmp21 antikoerper, P24(DELTA) antikoerper, S31I125 antikoerper, S31III125 antikoerper, TMP21 antikoerper, Tmp-21-I antikoerper, p23 antikoerper, 1110014C03Rik antikoerper, Tmp21 antikoerper, p24delta1 antikoerper, fe06g04 antikoerper, wu:fb98e10 antikoerper, wu:fe06g04 antikoerper, zgc:85681 antikoerper, transmembrane p24 trafficking protein 10 L homeolog antikoerper, transmembrane p24 trafficking protein 10 antikoerper, tmed10.L antikoerper, TMED10 antikoerper, Tmed10 antikoerper, tmed10 antikoerper

Hintergrund: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the γ-secretase but not theεsecretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the γ and ε-sites and can lead to the accumulation of the Aβ cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased γ-secretase activity but not ε-secretase activity, and increased Aβ production, demonstrating that TMP21 can modulate γsecretase activity.Synonyms: 21 kDa transmembrane-trafficking protein, S31I125, Transmembrane emp24 domain-containing protein 10, Transmembrane protein Tmp21

Gen-ID: 10972