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TRIM11 Antikörper (AbBy Fluor® 680)

TRIM11 Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 680
Produktnummer ABIN5010003
  • Target Alle TRIM11 Antikörper anzeigen
    TRIM11 (Tripartite Motif Containing 11 (TRIM11))
    Reaktivität
    • 48
    • 19
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 46
    • 2
    Kaninchen
    Klonalität
    • 48
    Polyklonal
    Konjugat
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRIM11 Antikörper ist konjugiert mit AbBy Fluor® 680
    Applikation
    • 37
    • 20
    • 18
    • 12
    • 6
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TRIM11/RNF92
    Isotyp
    IgG
    Top Product
    Discover our top product TRIM11 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TRIM11 (Tripartite Motif Containing 11 (TRIM11))
    Andere Bezeichnung
    RNF92 (TRIM11 Produkte)
    Synonyme
    BIA1 antikoerper, RNF92 antikoerper, TRIM11 antikoerper, tripartite motif containing 11 antikoerper, tripartite motif-containing 11 antikoerper, TRIM11 antikoerper, Trim11 antikoerper
    Hintergrund

    Synonyms: BIA 1, E3 ubiquitin protein ligase TRIM11, E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, RNF 92, TRI11_HUMAN, Trim 11, TRIM11, Tripartite mot containing 11, tripartite mot protein 11, Tripartite mot-containing protein 11.

    Background: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

    Gen-ID
    81559
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