TREX2 Antikörper (C-Term)

Produktnummer ABIN501038

Produktdetails anti-TREX2 Antikörper

Target: TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TREX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects TREX2. The antibody will not cross-react with the related protein TREX1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: TREX2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu TREX2

Target: TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))

Andere Bezeichnung: TREX2 (Trex2 Produkte)

Synonyme: RGD1562245 antikoerper, three prime repair exonuclease 2 antikoerper, TREX2 antikoerper, Trex2 antikoerper

Hintergrund: TREX2 is one of two major human 3\' to 5\' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.Synonyms: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2

Gen-ID: 11219

UniProt: Q9BQ50