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RNF216 Antikörper (N-Term)

RNF216 Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN501040
  • Target Alle RNF216 Antikörper anzeigen
    RNF216 (Ring Finger Protein 216 (RNF216))
    Bindungsspezifität
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 37
    • 30
    • 19
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 38
    Kaninchen
    Klonalität
    • 38
    Polyklonal
    Konjugat
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RNF216 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 13
    • 9
    • 9
    • 7
    • 7
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects RNF216 / TRIAD3.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse
    Aufreinigung
    Ion exchange chromatography
    Immunogen
    TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    RNF216 (Ring Finger Protein 216 (RNF216))
    Andere Bezeichnung
    RNF216 (RNF216 Produkte)
    Synonyme
    RGD1565135 antikoerper, TRIAD3 antikoerper, RNF216 antikoerper, zin antikoerper, u7i1 antikoerper, triad3 antikoerper, ubce7ip1 antikoerper, MGC147026 antikoerper, 2810055g22rik antikoerper, 2810055G22Rik antikoerper, AI647468 antikoerper, AU019462 antikoerper, C86502 antikoerper, F830018F18Rik antikoerper, UIP83 antikoerper, Ubce7ip1 antikoerper, CAHH antikoerper, U7I1 antikoerper, UBCE7IP1 antikoerper, ZIN antikoerper, ring finger protein 216 antikoerper, Rnf216 antikoerper, RNF216 antikoerper, rnf216 antikoerper
    Hintergrund
    Activation of NF-kappaB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9, this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).Synonyms: E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, UBCE7IP1, Ubiquitin-conjugating enzyme 7-interacting protein 1, ZIN, Zinc finger protein inhibiting NF-kappa-B
    Gen-ID
    54476
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