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Sphingomyelin Synthase 1 Antikörper (AA 331-413) (AbBy Fluor® 680)

SGMS1 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 680
Produktnummer ABIN5010925
  • Target Alle Sphingomyelin Synthase 1 (SGMS1) Antikörper anzeigen
    Sphingomyelin Synthase 1 (SGMS1)
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 331-413
    Reaktivität
    • 28
    • 20
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Maus
    Wirt
    • 42
    Kaninchen
    Klonalität
    • 42
    Polyklonal
    Konjugat
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sphingomyelin Synthase 1 Antikörper ist konjugiert mit AbBy Fluor® 680
    Applikation
    • 38
    • 20
    • 15
    • 12
    • 12
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Sphingomyelin Synthase 1
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Sphingomyelin Synthase 1 (SGMS1)
    Andere Bezeichnung
    Sphingomyelin Synthase 1 (SGMS1 Produkte)
    Synonyme
    MGC81436 antikoerper, TMEM23 antikoerper, MOB antikoerper, MOB1 antikoerper, SMS1 antikoerper, hmob33 antikoerper, 9530058O11Rik antikoerper, AI841905 antikoerper, C80702 antikoerper, Mob antikoerper, Sms1 antikoerper, Sor1 antikoerper, Tmem23 antikoerper, sphingomyelin synthase 1 antikoerper, sphingomyelin synthase 1 S homeolog antikoerper, phosphatidylcholine:ceramide cholinephosphotransferase 1 antikoerper, SGMS1 antikoerper, sgms1.S antikoerper, LOC100013212 antikoerper, Sgms1 antikoerper
    Hintergrund

    Synonyms: MOB, MOB1, SMS1, TMEM23, hmob33, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1

    Background: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

    Gen-ID
    259230
    UniProt
    Q86VZ5
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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