UBE2N Antikörper (C-Term)

Produktnummer ABIN501096

Produktdetails anti-UBE2N Antikörper

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2N Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects UBE2N / BLU.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Ion exchange chromatography

Immunogen: UBC13 antibody was raised against a peptide corresponding to 15 amino acids near the C- terminus of human UBC13.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UBE2N

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Abstract: UBE2N Produkte

Synonyme: UBC13 antikoerper, UbcH-ben antikoerper, UbcH13 antikoerper, 1500026J17Rik antikoerper, AL022654 antikoerper, BB101821 antikoerper, ube2n antikoerper, wu:fb11b03 antikoerper, wu:fc08b06 antikoerper, zgc:55726 antikoerper, ubc13 antikoerper, ubch-ben antikoerper, UBE2N antikoerper, ube2nl antikoerper, zgc:63901 antikoerper, ubiquitin conjugating enzyme E2 N antikoerper, ubiquitin-conjugating enzyme E2N antikoerper, ubiquitin conjugating enzyme E2 N S homeolog antikoerper, ubiquitin-conjugating enzyme E2Na antikoerper, ubiquitin-conjugating enzyme E2Nb antikoerper, UBE2N antikoerper, Ube2n antikoerper, ube2n.S antikoerper, ube2na antikoerper, LOC100533434 antikoerper, ube2n antikoerper, ube2nb antikoerper

Hintergrund: Ubiquitin-conjugating enzyme 13 (Ubc13) was initially discovered in S. cerevisiae as a DNA-damage inducible protein involved in the error-free DNA postreplication repair pathway (1). It has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). Ubc13 is part of a dimeric ubiquitin-conjugating enzyme complex also containing UEV1A (ubiquitin-conjugating enzyme E2 variant 1) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).Synonyms: Bendless-like ubiquitin-conjugating enzyme, UBC13, Ubiquitin carrier protein N, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-protein ligase N

Gen-ID: 7334

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway