BN antikoerper, GRP-10 antikoerper, preproGRP antikoerper, proGRP antikoerper, grp antikoerper, GRP2 antikoerper, ucma antikoerper, zgc:162317 antikoerper, C10orf49 antikoerper, GRP antikoerper, RGD1308977 antikoerper, 1110017I16Rik antikoerper, AW121955 antikoerper, Grp antikoerper, GRP1 antikoerper, zgc:85838 antikoerper, gastrin releasing peptide antikoerper, upper zone of growth plate and cartilage matrix associated antikoerper, upper zone of growth plate and cartilage matrix associated L homeolog antikoerper, upper zone of growth plate and cartilage matrix associated a antikoerper, upper zone of growth plate and cartilage matrix associated b antikoerper, GRP antikoerper, UCMA antikoerper, ucma.L antikoerper, ucmaa antikoerper, ucma antikoerper, Ucma antikoerper, ucmab antikoerper
Hintergrund
UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.Synonyms: C10orf49, Unique cartilage matrix-associated protein