UBE2O Antikörper (AA 1201-1292) (AbBy Fluor® 750)
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- Target Alle UBE2O Antikörper anzeigen
- UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
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Bindungsspezifität
- AA 1201-1292
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser UBE2O Antikörper ist konjugiert mit AbBy Fluor® 750
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Mouse,Rat,Pig,Horse,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human UBE2O/E2 230K
- Isotyp
- IgG
- Top Product
- Discover our top product UBE2O Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
- Andere Bezeichnung
- UBE2O (UBE2O Produkte)
- Synonyme
- e2-230k antikoerper, E2-230K antikoerper, 9630022H21 antikoerper, B230113M03Rik antikoerper, mKIAA1734 antikoerper, RGD1310297 antikoerper, ubiquitin conjugating enzyme E2 O antikoerper, ubiquitin-conjugating enzyme E2O antikoerper, UBE2O antikoerper, ube2o antikoerper, Ube2o antikoerper
- Hintergrund
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Synonyms: E2 230K, ubiquitin-conjugating enzyme E2O, EC=6.3.2.19, FLJ12878, KIAA1734, Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme, RP23 193A16.5, UBE2O, UBE2O_HUMAN, Ubiquitin carrier protein O, Ubiquitin conjugating enzyme E2 O, ubiquitin conjugating enzyme E2O.
Background: UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
- Gen-ID
- 63893
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