SCNN1A Antikörper (AA 46-68) (PE)
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- Target Alle SCNN1A Antikörper anzeigen
- SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
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Bindungsspezifität
- AA 46-68
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SCNN1A Antikörper ist konjugiert mit PE
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- Detects ~85 kDa.
- Kreuzreaktivität
- Maus, Ratte
- Aufreinigung
- Protein G Purified
- Immunogen
- Synthetic peptide from the N-terminal of Rat ENaC alpha (aa. 46-68)
- Klon
- 2G4
- Isotyp
- IgG2b
- Top Product
- Discover our top product SCNN1A Primärantikörper
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- Applikationshinweise
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- WB (1:1000)
- IHC (1:150)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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A 1:1000 dilution of ABIN5066873 was sufficient for detection of ENaC alpha in 15 μg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
- Andere Bezeichnung
- ENaC alpha (SCNN1A Produkte)
- Synonyme
- BESC2 antikoerper, ENaCa antikoerper, ENaCalpha antikoerper, SCNEA antikoerper, SCNN1 antikoerper, ENaC antikoerper, Scnn1 antikoerper, mENaC antikoerper, SCNN1A antikoerper, alphaxENaC antikoerper, besc2 antikoerper, enaca antikoerper, scnn1 antikoerper, ENAC antikoerper, sodium channel epithelial 1 alpha subunit antikoerper, sodium channel, nonvoltage-gated 1 alpha antikoerper, sodium channel, non voltage gated 1 alpha subunit L homeolog antikoerper, Scnn1a antikoerper, SCNN1A antikoerper, scnn1a.L antikoerper
- Hintergrund
- The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
- Gen-ID
- 25122
- NCBI Accession
- NP_113736
- UniProt
- Q6IRJ1
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