CD19 Antikörper

Produktnummer ABIN509573

Produktdetails anti-CD19 Antikörper

Target: CD19 (CD19 Molecule (CD19))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD19 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Spezifität: The mouse monoclonal antibody 4G7 recognizes an extracellular epitope of human CD19.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Human CCL (chronic lymphocytic leukemia) cells

Klon: 4G7

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytrometry: Recommended dilution: 1 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-CD19 Antikörper (ABIN509573)

Andersen, Pedersen, Woetmann, Villingshøj, Stockhausen, Odum, Poulsen: "EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 122, Issue 2, pp. 342-9, (2007) (PubMed).

Martino, Tonelli, Montemurro, Franzoni, Marino, Fazzina, Pession: "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)." in: Oncology reports, Vol. 15, Issue 1, pp. 207-11, (2005) (PubMed).

Köller, Zwölfer, Steiner, Smolen, Scheinecker: "Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients." in: International immunology, Vol. 16, Issue 11, pp. 1595-604, (2004) (PubMed).

Porcellini, Vallanti, Nozza, Poli, Lazzarin, Tambussi, Siccardi, Grassi: "Improved thymopoietic potential in aviremic HIV infected individuals treated with HAART by intermittent IL-2 administration." in: AIDS, Vol. 17, Issue 11, pp. 1621-30, (2003) (PubMed).

Basu, Lynne, Ruiz, Aballa, Ferrell, Brackett: "Cytofluorographic identification of activated T-cell subpopulations in the semen of men with spinal cord injuries." in: Journal of andrology, Vol. 23, Issue 4, pp. 551-6, (2002) (PubMed).

Dubois, Massacrier, Caux: "Selective attraction of naive and memory B cells by dendritic cells." in: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 633-41, (2001) (PubMed).

Stockmeyer, Dechant, van Egmond, Tutt, Sundarapandiyan, Graziano, Repp, Kalden, Gramatzki, Glennie, van de Winkel, Valerius: "Triggering Fc alpha-receptor I (CD89) recruits neutrophils as effector cells for CD20-directed antibody therapy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 10, pp. 5954-61, (2000) (PubMed).

Muench, Roncarolo, Namikawa: "Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver." in: Blood, Vol. 89, Issue 4, pp. 1364-75, (1997) (PubMed).

Details zu CD19

Target: CD19 (CD19 Molecule (CD19))

Andere Bezeichnung: CD19 (CD19 Produkte)

Synonyme: B4 antikoerper, CVID3 antikoerper, AW495831 antikoerper, CD19 antikoerper, CD19 molecule antikoerper, CD19 antigen antikoerper, CD19 antikoerper, Cd19 antikoerper

Hintergrund: CD19 Molecule,CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.,B4, Leu-12, CVID3

Gen-ID: 930

UniProt: P15391

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung