FAM105B Antikörper (C-Term)

Produktnummer ABIN5517806

Produktdetails anti-FAM105B Antikörper

Target: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein, Kaninchen, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM105B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NRAIELYNDK EKGKEVPFFS VLLFARDTSN DPGQLLRNHL NQVGHTGGLE

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against FAM105B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human FAM105B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FAM105B

Target: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Andere Bezeichnung: FAM105B (FAM105B Produkte)

Synonyme: C79097 antikoerper, OTU deubiquitinase with linear linkage specificity antikoerper, OTULIN antikoerper, Otulin antikoerper

Hintergrund: FAM105B is a deubiquitinase that specifically removes linear ('M-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis. It associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. It is required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. FAM105B acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex

Alias Symbols: -

Protein Interaction Partner: FAM168A, DAZAP2, UBC, SHARPIN, RNF31, RBCK1, VCP, TNF, DVL2, DSTN, CUL4A, ELAVL1,

Protein Size: 352

Gen-ID: 90268

NCBI Accession: NM_138348, NP_612357

UniProt: Q96BN8