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POLI Antikörper (C-Term)

POLI Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5531016
  • Target Alle POLI Antikörper anzeigen
    POLI (Polymerase (DNA Directed) iota (POLI))
    Bindungsspezifität
    • 15
    • 7
    • 7
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 673-701, C-Term
    Reaktivität
    • 40
    • 26
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 52
    • 3
    Kaninchen
    Klonalität
    • 52
    • 3
    Polyklonal
    Konjugat
    • 20
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser POLI Antikörper ist unkonjugiert
    Applikation
    • 27
    • 27
    • 17
    • 13
    • 13
    • 5
    • 4
    • 4
    • 3
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This POLI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-701 amino acids from the C-terminal region of human POLI.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product POLI Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    POLI (Polymerase (DNA Directed) iota (POLI))
    Andere Bezeichnung
    POLI (POLI Produkte)
    Synonyme
    poli antikoerper, wu:fc27h11 antikoerper, zgc:110185 antikoerper, GB12093 antikoerper, NV16187 antikoerper, RAD30B antikoerper, RAD3OB antikoerper, Rad30b antikoerper, DNA polymerase iota antikoerper, polymerase (DNA directed) iota antikoerper, polymerase (DNA directed), iota antikoerper, POLI antikoerper, poli antikoerper, LOC551219 antikoerper, AFUA_4G11140 antikoerper, LOC5568276 antikoerper, Pol-iota antikoerper, Poli antikoerper
    Hintergrund
    Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
    Molekulargewicht
    83 kDa
    Gen-ID
    11201
    UniProt
    Q9UNA4
    Pathways
    DNA Reparatur
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