POLI Antikörper (C-Term)
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- Target Alle POLI Antikörper anzeigen
- POLI (Polymerase (DNA Directed) iota (POLI))
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Bindungsspezifität
- AA 673-701, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser POLI Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This POLI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-701 amino acids from the C-terminal region of human POLI.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product POLI Primärantikörper
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- Applikationshinweise
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- POLI (Polymerase (DNA Directed) iota (POLI))
- Andere Bezeichnung
- POLI (POLI Produkte)
- Synonyme
- poli antikoerper, wu:fc27h11 antikoerper, zgc:110185 antikoerper, GB12093 antikoerper, NV16187 antikoerper, RAD30B antikoerper, RAD3OB antikoerper, Rad30b antikoerper, DNA polymerase iota antikoerper, polymerase (DNA directed) iota antikoerper, polymerase (DNA directed), iota antikoerper, POLI antikoerper, poli antikoerper, LOC551219 antikoerper, AFUA_4G11140 antikoerper, LOC5568276 antikoerper, Pol-iota antikoerper, Poli antikoerper
- Hintergrund
- Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
- Molekulargewicht
- 83 kDa
- Gen-ID
- 11201
- UniProt
- Q9UNA4
- Pathways
- DNA Reparatur
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