DUSP14 Antikörper (C-Term)

Produktnummer ABIN5531046

Produktdetails anti-DUSP14 Antikörper

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Bindungsspezifität: AA 168-198, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This DUSP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the C-terminal region of human DUSP14.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For IHC-P starting dilution is: 1:50~100

For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DUSP14

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Andere Bezeichnung: DUSP14 (DUSP14 Produkte)

Synonyme: MGC84083 antikoerper, zgc:101746 antikoerper, DUSP14 antikoerper, mkp-l antikoerper, mkp6 antikoerper, MKP-L antikoerper, MKP6 antikoerper, 1110014C10Rik antikoerper, 2310042C07Rik antikoerper, D11Ertd395e antikoerper, Mkp6 antikoerper, dual specificity phosphatase 14 antikoerper, dual specificity phosphatase 14 L homeolog antikoerper, DUSP14 antikoerper, dusp14.L antikoerper, dusp14 antikoerper, Dusp14 antikoerper

Hintergrund: DUSP14 is involved in the inactivation of MAP kinases. This proein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 (CD80) and B7-2 (CD86) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.

Molekulargewicht: 22 kDa

Gen-ID: 11072

UniProt: O95147