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GCAP1 Antikörper (C-Term)

GUCA1A Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5531246
  • Target Alle GCAP1 (GUCA1A) Antikörper anzeigen
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Bindungsspezifität
    • 15
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    AA 160-191, C-Term
    Reaktivität
    • 20
    • 18
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 34
    • 1
    Kaninchen
    Klonalität
    • 34
    • 1
    Polyklonal
    Konjugat
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GCAP1 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 17
    • 13
    • 13
    • 10
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product GUCA1A Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Andere Bezeichnung
    GCAP1 (GUCA1A Produkte)
    Synonyme
    C6orf131 antikoerper, COD3 antikoerper, CORD14 antikoerper, GCAP antikoerper, GCAP1 antikoerper, GUCA antikoerper, GUCA1 antikoerper, dJ139D8.6 antikoerper, MGC84170 antikoerper, GUCA1A antikoerper, guca1a antikoerper, MGC146317 antikoerper, GC-A antikoerper, Gcap1 antikoerper, Guca1 antikoerper, mGCAP1 antikoerper, gcap1 antikoerper, guanylate cyclase activator 1A antikoerper, guanylate cyclase activator 1A L homeolog antikoerper, guanylate cyclase activator 1A (retina) antikoerper, guanylate cyclase activator 1a (retina) antikoerper, GUCA1A antikoerper, Guca1a antikoerper, guca1a.L antikoerper, guca1a antikoerper
    Hintergrund
    Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
    Molekulargewicht
    23 kDa
    Gen-ID
    2978
    UniProt
    P43080
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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