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ADRA2B Antikörper (AA 343-369)

ADRA2B Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5532815
  • Target Alle ADRA2B Antikörper anzeigen
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Bindungsspezifität
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 343-369
    Reaktivität
    • 22
    • 5
    • 4
    Human
    Wirt
    • 22
    • 2
    • 1
    Kaninchen
    Klonalität
    • 23
    • 2
    Polyklonal
    Konjugat
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ADRA2B Antikörper ist unkonjugiert
    Applikation
    • 16
    • 9
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ADRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-369 amino acids from the Central region of human ADRA2B.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ADRA2B Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100

    For FACS starting dilution is: 1:10~50

    For IF starting dilution is: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Andere Bezeichnung
    ADRA2B (ADRA2B Produkte)
    Synonyme
    ADRA2L1 antikoerper, ADRA2RL1 antikoerper, ADRARL1 antikoerper, ALPHA2BAR antikoerper, alpha-2BAR antikoerper, Adra-2b antikoerper, [a]2B antikoerper, alpha2-C2 antikoerper, alpha2B antikoerper, ADRA2B antikoerper, zgc:194747 antikoerper, Adra2b antikoerper, adrenoceptor alpha 2B antikoerper, adrenergic receptor, alpha 2b antikoerper, adrenergic, alpha-2B-, receptor antikoerper, adrenoceptor alpha 2C antikoerper, ADRA2B antikoerper, Adra2b antikoerper, ADRA2C antikoerper, adra2b antikoerper
    Hintergrund
    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
    Molekulargewicht
    50 kDa
    Gen-ID
    151
    UniProt
    P18089
    Pathways
    EGFR Signaling Pathway, cAMP Metabolic Process
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