CDKL5 Antikörper (C-Term)

Produktnummer ABIN5533930

Produktdetails anti-CDKL5 Antikörper

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Bindungsspezifität: AA 982-1012, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKL5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CDKL5

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Andere Bezeichnung: CDKL5 (CDKL5 Produkte)

Synonyme: issx antikoerper, stk9 antikoerper, EIEE2 antikoerper, ISSX antikoerper, STK9 antikoerper, BC038161 antikoerper, Stk9 antikoerper, cyclin dependent kinase like 5 antikoerper, cyclin-dependent kinase-like 5 antikoerper, CDKL5 antikoerper, cdkl5 antikoerper, Cdkl5 antikoerper

Hintergrund: Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.

Molekulargewicht: 116 kDa

Gen-ID: 6792

UniProt: O76039

Pathways: Regulation of Cell Size