PSMD10 Antikörper (AA 43-76)
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- Target Alle PSMD10 Antikörper anzeigen
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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Bindungsspezifität
- AA 43-76
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PSMD10 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This PSMD10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 43-76 amino acids from the Central region of human PSMD10.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product PSMD10 Primärantikörper
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- Applikationshinweise
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For IF starting dilution is: 1:25
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.48 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Andere Bezeichnung
- PSMD10 (PSMD10 Produkte)
- Synonyme
- gankyrin antikoerper, zgc:109707 antikoerper, dJ889N15.2 antikoerper, p28 antikoerper, p28(GANK) antikoerper, AW554874 antikoerper, p28Gank antikoerper, proteasome 26S subunit, non-ATPase 10 antikoerper, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 antikoerper, psmd10 antikoerper, PSMD10 antikoerper, Psmd10 antikoerper
- Hintergrund
- Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
- Molekulargewicht
- 24 kDa
- Gen-ID
- 5716
- UniProt
- O75832
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
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