TEP1 Antikörper (N-Term)

Produktnummer ABIN5541415

Produktdetails anti-TEP1 Antikörper

Target: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Species: Human, Mouse and Rat.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to 20 Amino Acid peptide from near the amino terminus of human TP1.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TEP1

Target: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Andere Bezeichnung: tep1,tlp1 (TEP1 Produkte)

Synonyme: TLP1 antikoerper, TP1 antikoerper, TROVE1 antikoerper, VAULT2 antikoerper, p240 antikoerper, Tp1 antikoerper, Tlp1 antikoerper, telomerase associated protein 1 antikoerper, TEP1 antikoerper, Tep1 antikoerper

Hintergrund: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

UniProt: Q99973

Pathways: Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagie, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor