The 33A10 -defined antigen is the orphan protein, Placenta expressed transcript (Plet)-1. reactivity is identified in the developing mouse mammary gland, in the bronchioles of the lung, the salivary glands and the skin. Plet-1 is a product specific for keratinocytes undergoing terminal trichilemmal differentiation in the hair follicle and is expressed at the plasma membranes.
Aufreinigung
Purified
Immunogen
Derived by fusion of SP2/0 Mouse myeloma cells with spleen cells of Sprague-Dawley rats immunized with Mouse mammary tumor cells.
Biochemical data indicated that Plet-1 is a glycosylphosphatidylinositol-anchored glycoprotein with N-linked carbohydrates in addition to other posttranslational modifications. Plet-1 is a a recently identified protein that as of yet has no known function and is not associated with any one family of proteins. Plet-1 is used as a cell surface marker present on stem/progenitor epithelial cells and in a number of tissues including thymus and skin, and on epithelial cell types in mammary gland, prostate, and pancreas.