RAN Antikörper (AA 1-216)

Produktnummer ABIN5542382

Produktdetails anti-RAN Antikörper

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Bindungsspezifität: AA 1-216

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: RAN Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human RAN (AA: 1-216) expressed in E. Coli.

Klon: 8D1A6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu RAN

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Andere Bezeichnung: RAN (RAN Produkte)

Synonyme: ARA24 antikoerper, Gsp1 antikoerper, TC4 antikoerper, ran antikoerper, ara24 antikoerper, gsp1 antikoerper, ran-1 antikoerper, tc4 antikoerper, RAN antikoerper, RANP1 antikoerper, AAF30287 antikoerper, CG1404 antikoerper, Dmel\CG1404 antikoerper, Ran antikoerper, dran antikoerper, l(1)G0075 antikoerper, ran10A antikoerper, fc16b04 antikoerper, wu:fc16b04 antikoerper, RAN, member RAS oncogene family antikoerper, RAN, member RAS oncogene family S homeolog antikoerper, CG1404 gene product from transcript CG1404-RC antikoerper, RAN antikoerper, Ran antikoerper, ran.S antikoerper, ran antikoerper

Hintergrund:

Description: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Aliases: TC4, Gsp1, ARA24

Molekulargewicht: 24.4kDa

Gen-ID: 5901

HGNC: 5901

UniProt: P62826

Pathways: Regulatorische RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus