TERT Antikörper (AA 1029-1132)
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- Target Alle TERT Antikörper anzeigen
- TERT (Telomerase Reverse Transcriptase (TERT))
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Bindungsspezifität
- AA 1029-1132
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TERT Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
- Verwendungszweck
- TERT Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human TERT (AA: 1029-1132) expressed in E. Coli.
- Klon
- 3H2C12
- Isotyp
- IgG1
- Top Product
- Discover our top product TERT Primärantikörper
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- TERT (Telomerase Reverse Transcriptase (TERT))
- Andere Bezeichnung
- TERT (TERT Produkte)
- Hintergrund
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Description: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Aliases: TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1
- Molekulargewicht
- 127kDa
- Gen-ID
- 7015
- HGNC
- 7015
- UniProt
- O14746
- Pathways
- Telomere Maintenance
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