DNMT3L Antikörper (AA 147-386)

Produktnummer ABIN5542515

Produktdetails anti-DNMT3L Antikörper

Target: DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Bindungsspezifität: AA 147-386

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DNMT3L Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: DNMT3L Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli.

Klon: 2D10H11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu DNMT3L

Target: DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Andere Bezeichnung: DNMT3L (TRDMT1 Produkte)

Synonyme: DNMT3L antikoerper, D6Ertd14e antikoerper, ecat7 antikoerper, DNA methyltransferase 3 like antikoerper, DNA (cytosine-5-)-methyltransferase 3-like antikoerper, DNMT3L antikoerper, Dnmt3l antikoerper

Hintergrund: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 43.6kDa

Gen-ID: 29947

HGNC: 29947

UniProt: Q9UJW3