HLA-DRA Antikörper (AA 26-254)
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- Target Alle HLA-DRA Antikörper anzeigen
- HLA-DRA (HLA Class II DR alpha (HLA-DRA))
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Bindungsspezifität
- AA 26-254
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser HLA-DRA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)
- Verwendungszweck
- HLA-DRA Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. Coli.
- Klon
- 1C11A5
- Isotyp
- IgG2b
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/100 - 1/500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- HLA-DRA (HLA Class II DR alpha (HLA-DRA))
- Andere Bezeichnung
- HLA-DRA (HLA-DRA Produkte)
- Synonyme
- HLA-DRA1 antikoerper, MLRW antikoerper, DR-alpha antikoerper, HLA-DRA antikoerper, Mamu-DRA1 antikoerper, major histocompatibility complex, class II, DR alpha L homeolog antikoerper, major histocompatibility complex, class II, DR alpha antikoerper, hla-dra.L antikoerper, HLA-DRA antikoerper, MAMU-DRA antikoerper, BOLA-DRA antikoerper
- Hintergrund
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Description: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Aliases: MLRW, HLA-DRA1
- Molekulargewicht
- 28.6kDa
- Gen-ID
- 3122
- HGNC
- 3858
- UniProt
- P01903
- Pathways
- T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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