RAD50 Antikörper (AA 228-359)

Produktnummer ABIN5542670

Produktdetails anti-RAD50 Antikörper

Target: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Bindungsspezifität: AA 228-359

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAD50 Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: RAD50 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human RAD50 (AA: 228-359) expressed in E. Coli.

Klon: 5A8E5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu RAD50

Target: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Andere Bezeichnung: RAD50 (RAD50 Produkte)

Hintergrund:

Description: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Aliases: NBSLD, RAD502, hRad50

Molekulargewicht: 154kDa

Gen-ID: 10111

HGNC: 10111

UniProt: Q92878

Pathways: DNA Reparatur, Protein targeting to Nucleus