c-MYC Antikörper (pSer62)

Produktnummer ABIN5557289

Produktdetails anti-c-MYC Antikörper

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Bindungsspezifität: pSer62

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser c-MYC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic peptide derived from human c-Myc(S62), around 50-100aa (phospho S62).

Klon: 1A7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Andere Bezeichnung: c-Myc (MYC Produkte)

Synonyme: MRTL antikoerper, MYCC antikoerper, bHLHe39 antikoerper, c-Myc antikoerper, CMYC antikoerper, c-myc antikoerper, C-MYC antikoerper, LOC100136746 antikoerper, ARC antikoerper, B430311C09Rik antikoerper, MYC antikoerper, NOP antikoerper, Nop30 antikoerper, RNCMYC antikoerper, mMyc antikoerper, AU016757 antikoerper, Myc2 antikoerper, Niard antikoerper, Nird antikoerper, cmyc antikoerper, zc-myc antikoerper, c-myc II antikoerper, myc-B antikoerper, myc2 antikoerper, myc1 antikoerper, CMyc antikoerper, zgc:55680 antikoerper, CG10798 antikoerper, D-Myc antikoerper, DM antikoerper, DMYc antikoerper, Dm antikoerper, Dmel\CG10798 antikoerper, Dmyc antikoerper, EG:BACN5I9.1 antikoerper, anon-WO03040301.171 antikoerper, bHLHe57 antikoerper, c-MYC antikoerper, d-myc antikoerper, dMYC antikoerper, dMyc antikoerper, dMyc1 antikoerper, da antikoerper, dm antikoerper, dm/dMyc antikoerper, dm/myc antikoerper, dmyc antikoerper, dmyc1 antikoerper, l(1)G0139 antikoerper, l(1)G0354 antikoerper, l(1)G0359 antikoerper, myc antikoerper, MYC proto-oncogene, bHLH transcription factor antikoerper, v-myc myelocytomatosis viral oncogene homolog antikoerper, nucleolar protein 3 (apoptosis repressor with CARD domain) antikoerper, myelocytomatosis oncogene antikoerper, MYC proto-oncogene, bHLH transcription factor a antikoerper, MYC proto-oncogene, bHLH transcription factor L homeolog antikoerper, MYC proto-oncogene, bHLH transcription factor S homeolog antikoerper, v-myc myelocytomatosis viral oncogene homolog (avian) antikoerper, MYC proto-oncogene, bHLH transcription factor b antikoerper, CG10798 gene product from transcript CG10798-RB antikoerper, MYC antikoerper, LOC100136746 antikoerper, Nol3 antikoerper, Myc antikoerper, myca antikoerper, myc.L antikoerper, myc.S antikoerper, mycb antikoerper

Hintergrund:

Synonyms: Avian myelocytomatosis viral oncogene homolog, bHLHe39, c Myc, c Myc Epitope Tag, c Myc Tag, Cellular myelocytomatosis oncogene, MGC105490, MRTL, Myc Epitope Tag, Myc protein, Myc proto oncogene protein, Myc proto-oncogene protein, Myc-related translation/localization regulatory factor, Myc2, myca, Myelocytomatosis oncogene a, Myelocytomatosis oncogene, Niard, Nird, Oncogene Myc, Protooncogene homologous to myelocytomatosis virus, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, V-Myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog avian, zc-myc.

Background: Epitope tags are useful for the labeling and detection of proteins usingimmunoblotting, immunoprecipitation and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria, yeast,insect and mammalian cell systems.The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

Gen-ID: 4609

UniProt: P01106

Pathways: p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt