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Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper

Reaktivität: Human, Hund FACS, WB, Func Wirt: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
Produktnummer ABIN5564228
  • Target Alle CD40L (Ruplizumab Biosimilar) Produkte
    CD40L (Ruplizumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    Human, Hund
    Wirt
    • 1
    • 1
    • 1
    Human
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 3
    Dieser CD40L (Ruplizumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)
    Spezifität
    Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.
    Kreuzreaktivität
    Hund, Human
    Kreuzreaktivität (Details)
    Cross-reacts with canine CD40L.
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.001EU/μg
    Immunogen
    Recombinant human CD40L.
    Klon
    Hu5c8
    Isotyp
    IgG1
  • Kommentare

    This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    In PBS.
    Konservierungsmittel
    Without preservative
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.
    Haltbarkeit
    12 months
  • Target
    CD40L (Ruplizumab Biosimilar)
    Abstract
    CD40L (Ruplizumab Biosimilar) Produkte
    Synonyme
    CD154 antikoerper, CD40L antikoerper, HIGM1 antikoerper, IGM antikoerper, IMD3 antikoerper, T-BAM antikoerper, TNFSF5 antikoerper, TRAP antikoerper, gp39 antikoerper, hCD40L antikoerper, CD40 ligand antikoerper, CD40LG antikoerper
    Substanzklasse
    Biosimilar
    Hintergrund
    CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
    UniProt
    P29965
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