TLR10 Antikörper (AA 100-369)

Produktnummer ABIN5564256

Produktdetails anti-TLR10 Antikörper

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Bindungsspezifität: AA 100-369

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Protein G purified.

Immunogen: Recombinant human TLR10 protein (aa 100-369).

Klon: ABM3C85

Isotyp: IgG2a

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 0.05 % BSA and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C.

Haltbarkeit: 12 months

Details zu TLR10

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Andere Bezeichnung: TLR10 (TLR10 Produkte)

Synonyme: TLR10 antikoerper, CD290 antikoerper, toll like receptor 10 antikoerper, toll-like receptor 10 antikoerper, TLR10 antikoerper, Tlr10 antikoerper

Hintergrund: TLR10 (Toll-like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1beta specifically after exposure to TLR2 ligands. Like TLR1 and TLR6, TLR10 has also been shown to form a heterodimer complex with TLR2 during Helicobacter pylori infection and that it could be involved in the recognition of FSL-1, LPS and flagellin. TLR10 is an important innate immune sensor of viral infection with a role in innate immune defense and immunopathology following viral and bacterial pathogen infection.

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades