Recognizes mouse and rat Slc7a8. Has been reported to work in human samples (Wirth,et al.; 2009), but was not tested in-house.Detects a -50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and othertissues, which is absent in knock-out animals. ln some tissues the antibody detects anadditional unknown 38kDa band.
Kreuzreaktivität (Details)
Other species not tested.Detects a ~50 kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38 kDa band.
Aufreinigung
Antigen affinity purified.
Immunogen
Synthetic peptide corresponding to a partial sequence of mouse Slc7a8 (Q9QXW9).
LAT2 antikoerper, LPI-PC1 antikoerper, Lat2 antikoerper, Lat4 antikoerper, XAA2 antikoerper, lat2 antikoerper, lpi-pc1 antikoerper, 4F2LC-5 antikoerper, AA408822 antikoerper, si:ch211-14a17.3 antikoerper, si:zc14a17.3 antikoerper, slc7a8 antikoerper, solute carrier family 7 member 8 antikoerper, solute carrier family 7 member 8 L homeolog antikoerper, solute carrier family 7 (amino acid transporter, L-type), member 8 antikoerper, solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 antikoerper, solute carrier family 7 (amino acid transporter light chain, L system), member 8b antikoerper, SLC7A8 antikoerper, Slc7a8 antikoerper, slc7a8.L antikoerper, slc7a8 antikoerper, slc7a8b antikoerper
Hintergrund
L-type amino acid transporter (LAT) family members are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.