C19ORF80 Antikörper

Produktnummer ABIN5564288

Produktdetails anti-C19ORF80 Antikörper

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C19ORF80 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: Recognizes human betatrophin.

Kreuzreaktivität: Human

Immunogen: Recombinant human betatrophin.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-C19ORF80 Antikörper (ABIN5564288)

Sun, Liu, Li, Tang, Zou, Chen, Zheng, Jiang, Shi: "Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice." in: International journal of molecular medicine, Vol. 39, Issue 4, pp. 936-948, (2017) (PubMed).

Details zu C19ORF80

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Andere Bezeichnung: Betatrophin (C19ORF80 Produkte)

Synonyme: ANGPTL8 antikoerper, PRO1185 antikoerper, PVPA599 antikoerper, RIFL antikoerper, TD26 antikoerper, angiopoietin like 8 antikoerper, ANGPTL8 antikoerper

Hintergrund: Betatrophin (RIFL, Lipasin, Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.