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Desmoplakin Antikörper (pSer2849)

Rockland 600-401-j65 DSP Reaktivität: Human ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Rockland
Produktnummer ABIN5596788
Hersteller Produkt- Nr.: 600-401-j65
  • Target Alle Desmoplakin (DSP) Antikörper anzeigen
    Desmoplakin (DSP)
    Bindungsspezifität
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer2849
    Reaktivität
    • 32
    • 15
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 27
    • 3
    • 2
    • 1
    Kaninchen
    Klonalität
    • 30
    • 3
    Polyklonal
    Konjugat
    • 22
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Desmoplakin Antikörper ist unkonjugiert
    Applikation
    • 14
    • 10
    • 10
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Hersteller Produkt- Nr.
    600-401-j65
    Hersteller
    Rockland
    Verwendungszweck
    Desmoplakin phospho S2849 Antibody
    Kreuzreaktivität (Details)
    A BLAST analysis was used to suggest cross-reactivity with mouse and human based on 100 % sequence homology.
    Produktmerkmale
    Synonyms: rabbit Anti-Desmoplakin pS2849 antibody, 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP, DPI, DPII
    Aufreinigung
    Anti-Desmoplakin pS2849 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of the S2849 human residue.
    Sterilität
    Sterile filtered
    Immunogen

    Immunogen: Anti-Desmoplakin pS2849 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the C-terminus of human Desmoplakin protein.

    Immunogen Type: Conjugated Peptide

    Isotyp
    IgG
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  • Applikationshinweise

    Application Note: Anti-Desmoplakin pS2849 antibody tested in ELISA and western blot and is useful for Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~331 kDa corresponding to the appropriate cell lysate or extract.

    Western Blot Dilution: 1 μg/mL

    ELISA Dilution: 1: 10,000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.67 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 30 % Glycerol

    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Haltbarkeit
    12 months
  • Target
    Desmoplakin (DSP)
    Andere Bezeichnung
    DSP (DSP Produkte)
    Hintergrund
    Background: Desmoplakin pS2849 is high molecular weight protein of desmosomes. It is a member of the plakin or cytolinker family and is involved in the organization of the desmosomal cadherin-plakoglobin complexes into plasma membrane domains in the anchoring of intermediate filaments to the desmosomes. The phosphorylation theoretically affects its association with epidermal, simple cytokeratins and VIM intermediate filaments. Defects in DSP are the cause of keratosis palmoplantaris striata II, Carvajal syndrome, and arrhythmogenic right ventricular cardiomyopathy 8. Anti-Desmoplakin pS2849 Antibody is ideal for researchers interested in Cell Structure research.
    UniProt
    P15924
    Pathways
    Cell-Cell Junction Organization
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