Filamin A Antikörper (AA 1-838)

Produktnummer ABIN560922

Produktdetails anti-Filamin A Antikörper

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Bindungsspezifität: AA 1-838

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Filamin A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Proximity Ligation Assay (PLA)

Verwendungszweck: Mouse monoclonal antibody raised against a full length recombinant FLNA.

Sequenz: MPSGKVAQPT ITDNKDGTVT VRYAPSEAGL HEMDIRYDNM HIPGSPLQFY VDYVNCGHVT AYGPGLTHGV VNKPATFTVN TKDAGEGGLS LAIEGPSKAE ISCTDNQDGT CSVSYLPVLP GDYSILVKYN EQHVPGSPFT ARVTGDDSMR MSHLKVGSAA DIPINISETD LSLLTATVVP PSGREEPCLL KRLRNGHVGI SFVPKETGEH LVHVKKNGQH VASSPIPVVI SQSEIGDASR VRVSGQGLHE GHTFEPAEFI IDTRDAGYGG LSLSIEGPSK VDINTEDLED GTCRVTYCPT EPGNYIINIK FADQHVPGSP FSVKVTGEGR VKESITRRRR APSVANVGSH CDLSLKIPEI SIQDMTAQVT SPSGKTHEAE IVEGENHTYC IRFVPAEMGT HTVSVKYKGQ HVPGSPFQFT VGPLGEGGAH KVRAGGPGLE RAEAGVPAEF SIWTREAGAG GLAIAVEGPS KAEISFEDRK DGSCGVAYVV QEPGDYEVSV KFNEEHIPDS PFVVPVASPS GDARRLTVSS LQESGLKVNQ PASFAVSLNG AKGAIDAKVH SPSGALEECY VTEIDQDKYA VRFIPRENGV YLIDVKFNGT HIPGSPFKIR VGEPGHGGDP GLVSAYGAGL EGGVTGNPAE FVVNTSNAGA GALSVTIDGP SKVKMDCQEC PEGYRVTYTP MAPGSYLISI KYGGPYHIGG SPFKAKVTGP RLVSNHSLHE TSSVFVDSLT KATCAPQHGA PGPGPADASK VVAKGLGLSK AYVGQKSSFT VDCSKAGNNM LLVGVHGPRT PCEEILVKHV GSRLYSVSYL LKDKGEYTLV VKWGDEHIPG SPYRVVVP

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: FLNA (AAH14654, 1 a.a. ~ 838 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon: 4E10-1B2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-Filamin A Antikörper (ABIN560922)

Mingione, Verdelli, Ferrero, Vaira, Guarnieri, Scillitani, Vicentini, Balza, Beretta, Terranegra, Vezzoli, Soldati, Corbetta: "Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors." in: Journal of molecular endocrinology, Vol. 58, Issue 2, pp. 91-103, (2016) (PubMed).

Parrini, Mei, Pisanti, Catarzi, Pucatti, Bianchini, Mascalchi, Bertini, Morrone, Cavaliere, Guerrini: "Familial periventricular nodular heterotopia, epilepsy and Melnick-Needles Syndrome caused by a single FLNA mutation with combined gain-of-function and loss-of-function effects." in: Journal of medical genetics, Vol. 52, Issue 6, pp. 405-12, (2015) (PubMed).

Bézie, Picarda, Tesson, Renaudin, Durand, Ménoret, Mérieau, Chiffoleau, Guillonneau, Caron, Anegon: "Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119686, (2015) (PubMed).

Peverelli, Giardino, Treppiedi, Vitali, Cambiaghi, Locatelli, Lasio, Spada, Lania, Mantovani: "Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells." in: Endocrinology, Vol. 155, Issue 8, pp. 2932-41, (2014) (PubMed).

Oegema, Hulst, Theuns-Valks, van Unen, Schot, Mancini, Schipper, de Wit, Sibbles, de Coo, Nanninga, Hofstra, Halley, Brooks: "Novel no-stop FLNA mutation causes multi-organ involvement in males." in: American journal of medical genetics. Part A, Vol. 161A, Issue 9, pp. 2376-84, (2013) (PubMed).

Sakane, Alamir Mahmoud Abdallah, Nakano, Honda, Kitamura, Imoto, Matsushita, Sasaki: "Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 18, Issue 9, pp. 810-22, (2013) (PubMed).

Peverelli, Mantovani, Vitali, Elli, Olgiati, Ferrero, Laws, Della Mina, Villa, Beck-Peccoz, Spada, Lania: "Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs." in: The Journal of clinical endocrinology and metabolism, Vol. 97, Issue 3, pp. 967-77, (2012) (PubMed).

Valente, Logan, Mougou-Zerelli, Lee, Silhavy, Brancati, Iannicelli, Travaglini, Romani, Illi, Adams, Szymanska, Mazzotta, Lee, Tolentino, Swistun, Salpietro, Fede, Gabriel, Russ, Cibulskis, Sougnez et al.: "Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. ..." in: Nature genetics, Vol. 42, Issue 7, pp. 619-25, (2010) (PubMed).

Details zu Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Andere Bezeichnung: FLNA (FLNA Produkte)

Synonyme: ABP-280 antikoerper, ABPX antikoerper, CSBS antikoerper, CVD1 antikoerper, FLN antikoerper, FLN-A antikoerper, FLN1 antikoerper, FMD antikoerper, MNS antikoerper, NHBP antikoerper, OPD antikoerper, OPD1 antikoerper, OPD2 antikoerper, XLVD antikoerper, XMVD antikoerper, fb98b06 antikoerper, wu:fb98b06 antikoerper, wu:fd09g03 antikoerper, wu:fd49a06 antikoerper, Dilp2 antikoerper, F730004A14Rik antikoerper, Fln1 antikoerper, filamin-1 antikoerper, RGD1560614 antikoerper, MGC147094 antikoerper, CG3937 antikoerper, Cher antikoerper, Dmel\\CG3937 antikoerper, Fil antikoerper, joy antikoerper, sko antikoerper, filamin A antikoerper, filamin A, alpha (actin binding protein 280) antikoerper, filamin, alpha antikoerper, filamin-A antikoerper, cheerio antikoerper, FLNA antikoerper, flna antikoerper, Flna antikoerper, LOC587317 antikoerper, cher antikoerper, LOC100380643 antikoerper

Hintergrund: Full Gene Name: filamin A, alpha (actin binding protein 280)
Synonyms: ABP-280,ABPX,DKFZp434P031,FLN,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2

Gen-ID: 2316

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location