BTRC Antikörper (AA 24-151)

Produktnummer ABIN5611131

Produktdetails anti-BTRC Antikörper

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Bindungsspezifität: AA 24-151

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BTRC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. coli.

Klon: 4C5D8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu BTRC

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Andere Bezeichnung: BTRC (BTRC Produkte)

Synonyme: BTRC antikoerper, Beta-TrCP antikoerper, betaTrCP antikoerper, btrcp antikoerper, btrcp1 antikoerper, fbw1a antikoerper, fbxw1 antikoerper, fbxw1a antikoerper, fwd1 antikoerper, btrc antikoerper, beta-TrCP antikoerper, BETA-TRCP antikoerper, FBW1A antikoerper, FBXW1 antikoerper, FBXW1A antikoerper, FWD1 antikoerper, bTrCP antikoerper, bTrCP1 antikoerper, beta-TrCP1 antikoerper, btrc-a antikoerper, Beta-Trcp1 antikoerper, Fbw1a antikoerper, HOS antikoerper, Slimb antikoerper, b-TrCP antikoerper, mKIAA4123 antikoerper, beta-transducin repeat containing E3 ubiquitin protein ligase antikoerper, beta-transducin repeat containing antikoerper, beta-TrCP antikoerper, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog antikoerper, beta-transducin repeat containing protein antikoerper, BTRC antikoerper, btrc antikoerper, LOC100634006 antikoerper, Btrc antikoerper, btrc.S antikoerper

Hintergrund:

Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Aliases: FWD1, FBW1A, FBXW1, bTrCP, FBXW1A, bTrCP1, betaTrCP, BETA-TRCP

Molekulargewicht: 68.9 kDa

Gen-ID: 8945

HGNC: 8945

Pathways: Zellzyklus, Hedgehog Signalweg