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MPL Antikörper (AA 26-175)

MPL Reaktivität: Human WB, ELISA, FACS, IHC, ICC, Neut Wirt: Maus Monoclonal 1D6B7 unconjugated
Produktnummer ABIN5611182
  • Target Alle MPL Antikörper anzeigen
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    Bindungsspezifität
    • 32
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 26-175
    Reaktivität
    • 56
    • 26
    • 22
    • 1
    • 1
    Human
    Wirt
    • 52
    • 7
    Maus
    Klonalität
    • 53
    • 6
    Monoklonal
    Konjugat
    • 20
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser MPL Antikörper ist unkonjugiert
    Applikation
    • 38
    • 35
    • 14
    • 13
    • 13
    • 9
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Neutralization (Neut)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human CD110 (AA: extra 26-175) expressed in E. coli.
    Klon
    1D6B7
    Isotyp
    IgG2a
    Top Product
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  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Target
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    Andere Bezeichnung
    CD110 (MPL Produkte)
    Synonyme
    C-MPL antikoerper, CD110 antikoerper, MPLV antikoerper, THCYT2 antikoerper, TPOR antikoerper, TPO-R antikoerper, c-mpl antikoerper, c-mpl-I antikoerper, c-mpl-II antikoerper, hlb219 antikoerper, MPL antikoerper, mpll antikoerper, tpor antikoerper, tpor.b antikoerper, MPL proto-oncogene, thrombopoietin receptor antikoerper, myeloproliferative leukemia virus oncogene antikoerper, MPL antikoerper, Mpl antikoerper, mpl antikoerper
    Hintergrund

    Description: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

    Aliases: MPL, MPLV, TPOR, C-MPL, THCYT2

    Molekulargewicht
    71.2 kDa
    Gen-ID
    4352
    HGNC
    4352
    Pathways
    JAK-STAT Signalweg
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