APAF1 Antikörper (AA 1138-1237)

Produktnummer ABIN5611196

Produktdetails anti-APAF1 Antikörper

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Bindungsspezifität: AA 1138-1237

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APAF1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Verwendungszweck: APAF1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human APAF1 (AA: 1138-1237) expressed in E. Coli.

Klon: 2H9A1

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100 - 1/500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu APAF1

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Andere Bezeichnung: APAF1 (APAF1 Produkte)

Synonyme: APAF1 antikoerper, ARK antikoerper, Apaf-1 antikoerper, Apaf1 antikoerper, CG6829 antikoerper, D-Apaf-1 antikoerper, DARK antikoerper, Dapaf-1 antikoerper, Dapaf-1/HAC-1 antikoerper, Dark antikoerper, Dark/Apaf-I antikoerper, Dark/Dapaf-1/HAC1 antikoerper, Dark/Hac-1/dApaf-1 antikoerper, Dark/Hac-1/dApaf1 antikoerper, Dmel\\CG6829 antikoerper, Hac-1 antikoerper, Hac-1/Dark antikoerper, Hac1 antikoerper, T1 antikoerper, anon-53Fa antikoerper, apaf-1 antikoerper, apaf1 antikoerper, arc antikoerper, ark antikoerper, dAPAF-1 antikoerper, dApaf-1 antikoerper, dApaf-1/DARK/HAC-1 antikoerper, dApaf1 antikoerper, dArk antikoerper, dapaf antikoerper, dapaf-1 antikoerper, dapaf-1L antikoerper, dapaf-1S antikoerper, dark antikoerper, dark/dapaf-1/hac-1 antikoerper, dark/hac-1/dapaf-1 antikoerper, hac-1 antikoerper, hac1 antikoerper, l(2)SH0173 antikoerper, APAF-1 antikoerper, CED4 antikoerper, 6230400I06Rik antikoerper, Apaf1l antikoerper, fog antikoerper, mKIAA0413 antikoerper, zgc:136543 antikoerper, Death-associated APAF1-related killer antikoerper, apoptotic peptidase activating factor 1 L homeolog antikoerper, apoptotic peptidase activating factor 1 antikoerper, Dark antikoerper, apaf1.L antikoerper, apaf1 antikoerper, APAF1 antikoerper, Apaf1 antikoerper

Hintergrund:

Description: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Aliases: CED4, APAF-1

Molekulargewicht: 141.8kDa

Gen-ID: 317

HGNC: 317

Pathways: p53 Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Tube Formation, Positive Regulation of Endopeptidase Activity