CTLA4 Antikörper (AA 36-161)
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- Target Alle CTLA4 Antikörper anzeigen
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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Bindungsspezifität
- AA 36-161
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CTLA4 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), ELISA
- Verwendungszweck
- CD152 Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human CD152 (AA: 36-161) expressed in E. Coli.
- Klon
- 8B3F8
- Isotyp
- IgG1
- Top Product
- Discover our top product CTLA4 Primärantikörper
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
- Andere Bezeichnung
- CD152 (CTLA4 Produkte)
- Hintergrund
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Description: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Aliases: CTLA4, CD, GSE, GRD4, ALPS5, CTLA-4, IDDM12, CELIAC3
- Molekulargewicht
- 24.6kDa
- Gen-ID
- 1493
- HGNC
- 1493
- UniProt
- P16410
- Pathways
- Cancer Immune Checkpoints
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