ATRX Antikörper (AA 2311-2492)
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- Target Alle ATRX Antikörper anzeigen
- ATRX (helicase 2, X-linked (ATRX))
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Bindungsspezifität
- AA 2311-2492
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser ATRX Antikörper ist unkonjugiert
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Applikation
- ELISA
- Verwendungszweck
- ATRX Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human ATRX (AA: 2311-2492) expressed in E. Coli.
- Klon
- 8B2H9
- Isotyp
- IgG1
- Top Product
- Discover our top product ATRX Primärantikörper
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- Applikationshinweise
- ELISA: 1/10000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- ATRX (helicase 2, X-linked (ATRX))
- Andere Bezeichnung
- ATRX (ATRX Produkte)
- Hintergrund
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Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Aliases: JMS, SHS, XH2, XNP, ATR2, SFM1, MRX52, RAD54, MRXHF1, RAD54L, ZNF-HX
- Molekulargewicht
- 282.5kDa
- Gen-ID
- 546
- HGNC
- 546
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