MUTYH Antikörper (AA 436-535)

Produktnummer ABIN561883

Produktdetails anti-MUTYH Antikörper

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Bindungsspezifität: AA 436-535

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUTYH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), RNA Interference (RNAi)

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant MUTYH.

Sequenz: KLTYQVYGLA LEGQTPVTTV PPGARWLTQE EFHTAAVSTA MKKVFRVYQG QQPGTCMGSK RSQVSSPCSR KKPRMGQQVL DNFFRSHIST DAHSLNSAAQ

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: MUTYH (AAH03178, 436 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon: 4D10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-MUTYH Antikörper (ABIN561883)

Komine, Shimodaira, Takao, Soeda, Zhang, Takahashi, Ishioka: "Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia Coli Strain." in: Human mutation, Vol. 36, Issue 7, pp. 704-11, (2015) (PubMed).

Shinmura, Goto, Tao, Kato, Suzuki, Nakamura, Matsuda, Yin, Morita, Kono, Sugimura: "Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 617351, (2014) (PubMed).

Agustina, Hahm, Han, Tran, Chung, Park, Park, Han: "Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation." in: BMC molecular biology, Vol. 15, pp. 17, (2014) (PubMed).

Raetz, Xie, Kundu, Brinkmeyer, Chang, David: "Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells." in: Carcinogenesis, Vol. 33, Issue 11, pp. 2301-9, (2012) (PubMed).

Hahm, Chung, Agustina, Han, Yoon, Park, Kang, Park, Na, Han: "Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells." in: Oncology letters, Vol. 4, Issue 6, pp. 1203-1208, (2012) (PubMed).

Suzuki, Harashima, Kamiya: "Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine." in: DNA repair, Vol. 9, Issue 5, pp. 542-50, (2010) (PubMed).

van der Post, Kets, Ligtenberg, van Krieken, Hoogerbrugge: "Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis." in: Virchows Archiv : an international journal of pathology, Vol. 454, Issue 1, pp. 25-9, (2008) (PubMed).

Details zu MUTYH

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Andere Bezeichnung: MUTYH (MUTYH Produkte)

Synonyme: MUTYH antikoerper, MGC145569 antikoerper, CYP2C antikoerper, MYH antikoerper, 5730495A01Rik antikoerper, Mutyha antikoerper, Mutyhalpha antikoerper, Mutyhb antikoerper, Mutyhbeta antikoerper, Mutyhc antikoerper, Myh antikoerper, mutY DNA glycosylase antikoerper, mutY homolog (E. coli) antikoerper, A/G-specific adenine DNA glycosylase-like antikoerper, MUTYH antikoerper, mutyh antikoerper, LOC100373318 antikoerper, Mutyh antikoerper

Hintergrund: Full Gene Name: mutY homolog (E. coli)
Synonyms: MGC4416,MYH

Gen-ID: 4595

Pathways: DNA Reparatur