CNOT3 Antikörper (AA 1-100)

Produktnummer ABIN562024

Produktdetails anti-CNOT3 Antikörper

Target: CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CNOT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant CNOT3.

Sequenz: MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: CNOT3 (NP_055331, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon: 4B8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-CNOT3 Antikörper (ABIN562024)

Inoue, Morita, Hijikata, Fukuda-Yuzawa, Adachi, Isono, Ikawa, Kawamoto, Koseki, Natsume, Fukao, Ohara, Yamamoto, Kurosaki: "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability." in: The Journal of experimental medicine, Vol. 212, Issue 9, pp. 1465-79, (2015) (PubMed).

Kamon, Katano, Hiraki-Kamon, Hishida, Nakachi, Mizuno, Okazaki, Suzuki, Hirasaki, Ueda, Nishimoto, Kato, Okuda: "Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells." in: Stem cells and development, Vol. 23, Issue 18, pp. 2170-9, (2014) (PubMed).

Doidge, Mittal, Aslam, Winkler: "The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex." in: PLoS ONE, Vol. 7, Issue 12, pp. e51331, (2012) (PubMed).

Aslam, Mittal, Koch, Andrau, Winkler: "The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation." in: Molecular biology of the cell, Vol. 20, Issue 17, pp. 3840-50, (2009) (PubMed).

Details zu CNOT3

Target: CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))

Andere Bezeichnung: CNOT3 (CNOT3 Produkte)

Hintergrund: Full Gene Name: CCR4-NOT transcription complex, subunit 3
Synonyms: KIAA0691,LENG2,NOT3,NOT3H

Gen-ID: 4849

NCBI Accession: NM_014516

Pathways: Stem Cell Maintenance