YAP1 Antikörper (AA 53-161)

Produktnummer ABIN564526

Produktdetails anti-YAP1 Antikörper

Target: YAP1 (Yes-Associated Protein 1 (YAP1))

Bindungsspezifität: AA 53-161

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser YAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant YAP1.

Sequenz: QIVHVRGDSE TDLEALFNAV MNPKTANVPQ TVPMRLRKLP DSFFKPPEPK SHSRQASTDA GTAGALTPQH VRAHSSPASL QLGAVSPGTL TPTGVVSGPA ATPTAQHLR

Kreuzreaktivität: Human, Maus

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: YAP1 (NP_006097, 53 a.a. ~ 161 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon: 2F12

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-YAP1 Antikörper (ABIN564526)

Toyooka, Oka, Fujimori: "Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes." in: Developmental biology, Vol. 411, Issue 1, pp. 50-60, (2016) (PubMed).

Abbassi, Malki, Cockburn, Macaulay, Robert, Rossant, Clarke: "Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis." in: Biology of reproduction, Vol. 94, Issue 5, pp. 102, (2016) (PubMed).

Junemann, Birgin, Erdmann, Schröder, Just, Gerhard, Pich: "Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells." in: Proteomics. Clinical applications, Vol. 11, Issue 3-4, (2016) (PubMed).

Yang, Zhang, Chen, Chen, Dong: "Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1." in: The Journal of biological chemistry, Vol. 290, Issue 10, pp. 6191-202, (2015) (PubMed).

Shao, Zhai, Del Re, Sciarretta, Yabuta, Nojima, Lim, Pan, Sadoshima: "A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response." in: Nature communications, Vol. 5, pp. 3315, (2014) (PubMed).

Adler, Heller, Bringman, Ranahan, Cocklin, Goebl, Oh, Lim, Ingham, Wells: "Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth." in: The Journal of biological chemistry, Vol. 288, Issue 21, pp. 15181-93, (2013) (PubMed).

Das, Tanigawa, Karner, Xin, Lum, Chen, Olson, Perantoni, Carroll: "Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation." in: Nature cell biology, Vol. 15, Issue 9, pp. 1035-44, (2013) (PubMed).

Yang, Zhang, Liu, Chong, Ding, Chen, Dong: "CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation." in: Cancer research, Vol. 73, Issue 22, pp. 6722-33, (2013) (PubMed).

Adler, Johnson, Heller, Bringman, Ranahan, Conwell, Sun, Hudmon, Wells: "Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 43, pp. 17368-73, (2013) (PubMed).

Skouloudaki, Walz: "YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation." in: PLoS ONE, Vol. 7, Issue 4, pp. e35735, (2012) (PubMed).

Hirate, Cockburn, Rossant, Sasaki: "Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 50, pp. E3389-90; author reply E3391-2, (2012) (PubMed).

Murakami, Mizuno, Taniguchi, Fujii, Ishiguro, Fukui, Akatsuka, Horio, Hida, Kondo, Toyokuni, Osada, Sekido: "LATS2 is a tumor suppressor gene of malignant mesothelioma." in: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).

Leivonen, Rokka, Ostling, Kohonen, Corthals, Kallioniemi, Perälä: "Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact." in: Molecular & cellular proteomics : MCP, Vol. 10, Issue 7, pp. M110.005322, (2011) (PubMed).

Sekido: "Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation." in: Pathology international, Vol. 61, Issue 6, pp. 331-44, (2011) (PubMed).

Wada, Itoga, Okano, Yonemura, Sasaki: "Hippo pathway regulation by cell morphology and stress fibers." in: Development (Cambridge, England), Vol. 138, Issue 18, pp. 3907-14, (2011) (PubMed).

Tomlinson, Gudmundsdottir, Luong, Leung, Knebel, Basu: "JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis." in: Cell death & disease, Vol. 1, pp. e29, (2011) (PubMed).

Lau, Murray, Houshmandi, Xu, Gutmann, Yu: "Merlin is a potent inhibitor of glioma growth." in: Cancer research, Vol. 68, Issue 14, pp. 5733-42, (2008) (PubMed).

Details zu YAP1

Target: YAP1 (Yes-Associated Protein 1 (YAP1))

Andere Bezeichnung: YAP1 (YAP1 Produkte)

Synonyme: YAP antikoerper, YAP2 antikoerper, YAP65 antikoerper, YKI antikoerper, xyap antikoerper, yap antikoerper, yap2 antikoerper, yap65 antikoerper, yki antikoerper, AI325207 antikoerper, Yap antikoerper, Yap65 antikoerper, Yki antikoerper, Yorkie antikoerper, cb194 antikoerper, sb:cb194 antikoerper, si:ch211-181p1.5 antikoerper, si:dkey-3b8.3 antikoerper, wu:fc18c04 antikoerper, zgc:158380 antikoerper, Yes associated protein 1 antikoerper, Yes associated protein 1 S homeolog antikoerper, yes-associated protein 1 antikoerper, Yes-associated protein 1 antikoerper, YAP1 antikoerper, yap1.S antikoerper, Yap1 antikoerper, yap1 antikoerper

Hintergrund: Full Gene Name: Yes-associated protein 1, 65 kDa
Synonyms: YAP,YAP2,YAP65,YKI

Gen-ID: 10413

NCBI Accession: NM_006106

Pathways: MAPK Signalweg, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha