Emerin Antikörper (AA 1-48)

Produktnummer ABIN5647115

Produktdetails anti-Emerin Antikörper

Target: Emerin (EMD)

Bindungsspezifität: AA 1-48

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Emerin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids 1-48 (MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL-human) were used as the immunogen for the Emerin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Emerin antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Emerin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Emerin

Target: Emerin (EMD)

Andere Bezeichnung: Emerin (EMD Produkte)

Synonyme: fj58f01 antikoerper, wu:fj58f01 antikoerper, EMD antikoerper, Bocks antikoerper, Bocksbeutel antikoerper, CG9424 antikoerper, Dmel\\CG9424 antikoerper, emerin antikoerper, emd antikoerper, xemd1 antikoerper, xemerin2 antikoerper, xemd2 antikoerper, xemerin1 antikoerper, EDMD antikoerper, LEMD5 antikoerper, STA antikoerper, AW550900 antikoerper, Sta antikoerper, emerin antikoerper, emerin (Emery-Dreifuss muscular dystrophy) antikoerper, bocksbeutel antikoerper, emerin L homeolog antikoerper, emerin S homeolog antikoerper, EMD antikoerper, emd antikoerper, bocks antikoerper, emd.L antikoerper, emd.S antikoerper, Emd antikoerper

Hintergrund: Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene. And this gene is mapped to Xq28. Emerin is a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Emery-Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene. Emerin appears to be involved in mechanotransduction, as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli. In cardiac muscle, emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs, and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta.

UniProt: P50402